Trail Blazers vs. Blazers odds, line, spread: 2025 NBA picks, January 6 predictions from proven model

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The Detroit Pistons will face off against the Portland Trail Blazers at 7 p.m. ET on Monday at Little Caesars Arena. Detroit is 17-18 overall and 8-8 at home, while Portland is 12-22 overall and 4-14 on the road. The Pistons are favored by 6.5 points in the latest Pistons vs. Trail Blazers odds, and the over/under is 224.5 points. Before entering any Trail Blazers vs. Pistons picks, you'll want to see the NBA predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past six-plus seasons. The model enters Week 11 of the 2024-25 NBA season on a sizzling 128-95 roll on all top-rated NBA picks dating back to last season, returning nearly $3,000. Anyone following at sportsbooks and betting apps could have seen huge returns.

The model has set its sights on Portland vs. Detroit. You can head to SportsLine to see its picks. Here are several NBA betting lines for the game:

Pistons vs. Trail Blazers spread: Pistons -6.5Pistons vs. Trail Blazers over/under: 224.5 pointsPistons vs. Trail Blazers money line: Pistons: -264, Trail Blazers: +213Pistons vs. Trail Blazers picks: See picks herePistons vs. Trail Blazers streaming: FuboTV (Try for free)Why the Pistons can cover

The Trail Blazers are hoping to do what the Timberwolves couldn't on Saturday: put an end to the Pistons' winning streak, which now stands at three games. The Pistons took down the Timberwolves 119-105.

Cade Cunningham was a one-man wrecking crew for the Pistons as he almost dropped a double-double with 40 points and nine assists. Cunningham has become a key player for the Pistons. Detroit is 7-3 when he scores at least 20 points, but 10-15 otherwise. For the season, Cunningham is averaging 24.1 points, 9.5 assists and 6.7 rebounds per game. See which team to pick here. 

Why the Trail Blazers can cover 

Meanwhile, the Trail Blazers are coming off an impressive 105-102 victory over the Milwaukee Bucks on Saturday. The Blazers have now won three of their past five games and have dominated this series in recent years. 

In fact, Portland is 8-1 in its last nine games against the Pistons. The Blazers are also 4-1 against the spread in their past five road games against Detroit. Portland enters Monday's matchup averaging 107.9 points per game while knocking down 44.6% of its field goals. See which team to pick here. 

How to make Pistons vs. Trail Blazers picks

The model has simulated Pistons vs. Trail Blazers 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits in well over 50% of simulations. You can only see the picks at SportsLine.

So who wins the Trail Blazers vs. Pistons on Monday, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Pistons vs. Trail Blazers spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.