Running back Saquon Barkley will miss his third straight game because of a sprained right ankle. Tight end and leading receiver Evan Engram is also inactive with a knee injury and receiver Sterling Shepard is in the concussion protocol. Barkley’s backup Wayne Gallman also is sitting out with a concussion. Shepard, Engram and Gallman were hurt Sunday in the 28-10 loss to the Minnesota Vikings.
Other players inactive for the Giants are guard Chad Slade, defensive tackle Eric Smith and linebacker Tae Davis. Other inactives for the Patriots are running back Damien Harris, quarterback Cody Kessler, offensive lineman Korey Cunningham, defensive lineman Byron Cowart cornerback Joejuan Williams.