The Welsh actress, 48, plays Griselda Blanco, who was a real-life Colombian drug lord killed in 2012 after stacking up an estimated 200 murders to her name.
The new trailer sees Griselda enjoying a rare moment of ecstasy with a young female lover, amid the high-octane environment she surrounds herself in.
Wearing nothing but a cream satin negligee open down to her navel, Catherine flashes her flesh while writhing against her brunette partner.
The pair share a lingering kiss as Griselda appears to be consumed by a rare moment of passion, while her partner trails her hand along her body.
Catherine Zeta-Jones has been seen in a racy lesbian love scene in her new film
Catherine plays Griselda Blanco in the biography
Griselda was one of the most notorious Colombian druglords
The Ocean’s Twelve actress is barely recognisable in the rest of the 90 second clip, fully immersing herself to play such a complicated real-life figure.
Wearing ageing make-up and often covered in a firmly tied headscarf, the role could be one of Catherine’s most memorable yet.
Catherine shines a light on the truth of Griselda’s harrowing existence in the voiceover, as she says: “I’ve been in prison since the day I was born. I’m used to it. Trust no-one in this life.”
What follows is a series of tense flashes filled with gunfire and an apparent death, as Griselda and her family struggle to evade the Drug Enforcement Administration - DEA - who are always hot on their heels.
The actress can be seen writhing in bed with a brunette female
In one moment, the trailer also teases the introduction of a young Pablo Escobar, one of the most notorious drug lords of the 20th Century.
“Have you ever worked for a woman before?” Griselda asks him with a thick Colombian accent.
Darcy Laurie, who plays the criminal, replies easily: “With all due respect, no one has.”
The Cocaine Godmother will be released January 20 on American television network Lifetime.